The rearrangement of genes for immunoglobulin
molecules in immature B cells and for
the T cell receptor in immature T cells involves
an excision mechanism. This requires precise
recognition to ensure formation of the correct
coding information. Noncoding DNA between
genes for different regions of the molecule is excised
and the remaining DNA is subsequently
rejoined (ligation). Unlike recombination
during meiosis, IgG rearrangements represent a
special type of recombination, since nonhomologous
DNA sequences are recombined.
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